The robust, sensitive, and selective detection of targeted biomolecules in their native
environment by prospective nanostructures holds much promise for real-time, accurate, and …

Psoriasis is a common inflammatory skin disease with an incompletely understood etiology.
The disease is characterized by red, scaly and well-demarcated skin lesions formed by the …

Highlights•Non-antibody scaffold drugs are a promising new class of biologics drugs.•The
first candidate scaffolds are now moving into clinical development and practice.•Challenges …

Non-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, small single-domain
proteins that require no post-translational modification, often lack disulfide bonds, and can …

The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …

Here we perform phage-assisted continuous evolution (PACE) of TEV protease, which
canonically cleaves ENLYFQS, to cleave a very different target sequence, HPLVGHM, that is …

Summary Interleukin-23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-
inflammatory T helper 17 cell responses linked to autoimmune and inflammatory diseases …

The emergence of novel binding proteins or antibody mimetics capable of binding to ligand
analytes in a manner analogous to that of the antigen–antibody interaction has spurred …

Cytokines of the IL-12 family show structural similarities but have distinct functions in the
immune system. Prominent members of this cytokine family are the pro-inflammatory …

Highlights•Enteroviruses cause many human diseases, yet no antiviral drugs are
available.•Capsids and viral enzymes are promising targets for direct-acting antiviral …