Immune checkpoint inhibitor (ICI) activates host's anti-tumor immune response by blocking
negative regulatory immune signals. A series of clinical trials showed that ICI could …

Vascular epidermal growth factor receptor-2 (VEGFR-2), as an important tyrosine
transmembrane protein, plays an important role in regulating endothelial cell proliferation …

Tyrosine kinases are important cellular signaling proteins that have a variety of biological
activities including cell proliferation and migration. Multiple kinases are involved in …

Identification of potent anticancer agents with high selectivity and low toxicity remains on the
way to human health. Pyridazine featuring advantageous physicochemical properties and …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Vascular endothelial growth factors (VEGFs) are critical regulators of vascular and lymphatic
function during development, in health and in disease. There are five mammalian VEGF …

Three new sets of quinazolinones bearing sulfachloropyridazine 4a-f, 6a-i and 8a-i were
designed and synthesized. All the synthesized compounds were screened for their in vitro …

Protein and lipid kinases fulfill essential roles in many signaling pathways that regulate
normal cell functions. Deregulation of these kinase activities lead to a variety of pathologies …

We report the synthesis of various phthalazines via a new cascade reaction, initiated by
visible light photocatalysis, involving a radical hydroamination reaction followed by a radical …

Introduction• Pathological markers of hypoxia‐Necrosis‐Hypoxia inducible factor (HIF)
targets‐HIF‐1 versus HIF‐2‐Early versus late stage cancer‐Intratumour heterogeneity …