The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …

DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …

To repair double-strand DNA breaks by homologous recombination, the 5′-terminated
DNA strand must first be resected, which generates 3′ single-stranded DNA overhangs …

The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …

RecA/Rad51 catalyzed pairing of homologous DNA strands, initiated by polymerization of
the recombinase on single-stranded DNA (ssDNA), is a universal feature of homologous …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

DNA double-strand breaks are repaired by different mechanisms, including homologous
recombination and nonhomologous end-joining. DNA-end resection, the first step in …

We show that hypomorphic mutations in hMRE11, but not in ATM, are present in certain
individuals with an ataxia-telangiectasia-like disorder (ATLD). The cellular features resulting …

▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …