AMPA receptor structure and auxiliary subunits

A Kamalova, T Nakagawa - The Journal of physiology, 2021 - Wiley Online Library
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

Proteomic insights into synaptic signaling in the brain: the past, present and future

Y Xu, X Song, D Wang, Y Wang, P Li, J Li - Molecular Brain, 2021 - Springer
Chemical synapses in the brain connect neurons to form neural circuits, providing the
structural and functional bases for neural communication. Disrupted synaptic signaling is …

[HTML][HTML] Differential regulation of evoked and spontaneous release by presynaptic NMDA receptors

T Abrahamsson, CYC Chou, SY Li, A Mancino… - Neuron, 2017 - cell.com
Presynaptic NMDA receptors (preNMDARs) control synaptic release, but it is not well
understood how. Rab3-interacting molecules (RIMs) provide scaffolding at presynaptic …

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

NK Hussain, GM Thomas, J Luo… - Proceedings of the …, 2015 - National Acad Sciences
AMPA receptors (AMPARs) are the major excitatory receptors of the brain and are
fundamental to synaptic plasticity, memory, and cognition. Dynamic recycling of AMPARs in …

Interaction proteomics reveals brain region-specific AMPA receptor complexes

N Chen, NJ Pandya, F Koopmans… - Journal of proteome …, 2014 - ACS Publications
Fast excitatory synaptic transmission in the brain is mediated by glutamate acting on
postsynaptic AMPA receptors. Recent studies have revealed a substantial number of AMPA …

SPARC and GluA1-containing AMPA receptors promote neuronal health following CNS injury

EV Jones, Y Bernardinelli, JG Zarruk… - Frontiers in cellular …, 2018 - frontiersin.org
The proper formation and maintenance of functional synapses in the central nervous system
(CNS) requires communication between neurons and astrocytes and the ability of astrocytes …

RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors

AP Thompson, C Bitsina, JL Gray, F von Delft… - Journal of Biological …, 2021 - ASBMB
The human dedicator of cytokinesis (DOCK) family consists of 11 structurally conserved
proteins that serve as atypical RHO guanine nucleotide exchange factors (RHO GEFs) …

[HTML][HTML] FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation

D Cook, E Nuro, EV Jones, HF Altimimi, WT Farmer… - Cell reports, 2014 - cell.com
Translational control of mRNAs allows for rapid and selective changes in synaptic protein
expression that are required for long-lasting plasticity and memory formation in the brain …

Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3

NF Shanks, O Cais, T Maruo, JN Savas… - Journal of …, 2014 - Soc Neuroscience
Cornichon homologs (CNIHs) are AMPA-type glutamate receptor (AMPAR) auxiliary
subunits that modulate AMPAR ion channel function and trafficking. Mechanisms underlying …

Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's Disease

Z Du, M Tertrais, G Courtand… - Frontiers in molecular …, 2017 - frontiersin.org
Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive
motor symptoms that are preceded by cognitive deficits and is considered as a disorder that …