[HTML][HTML] Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five
S Stegemann, C Moreton, S Svanbäck, K Box… - Drug Discovery …, 2023 - Elsevier
Highlights•Orally delivered drug products gradually continue to exceed the Rule-of-five on
Molecular Weight and clogP.•New predictive descriptors and tools, advanced chemistry and …
Molecular Weight and clogP.•New predictive descriptors and tools, advanced chemistry and …
Clinical experiences with venetoclax and other pro-apoptotic agents in lymphoid malignancies: lessons from monotherapy and chemotherapy combination
TE Lew, JF Seymour - Journal of Hematology & Oncology, 2022 - Springer
BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins
which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the …
which restore apoptosis in malignant cells. The only currently approved BH3-mimetic, the …
Famotidine-loaded solid self-nanoemulsifying drug delivery system demonstrates exceptional efficiency in amelioration of peptic ulcer
Famotidine (FMD) is a highly potent H 2-receptor antagonist used in peptic ulcer treatment.
However, the drug possesses poor aqueous solubility and permeability. FMD-loaded solid …
However, the drug possesses poor aqueous solubility and permeability. FMD-loaded solid …
Quality by design approach-based fabrication and evaluation of self-nanoemulsifying drug delivery system for improved delivery of venetoclax
Breast cancer is reported as one of the most prevalent non-cutaneous malignancies in
women. Venetoclax (VEN) is an approved BCl-2 inhibitor for the treatment of chronic …
women. Venetoclax (VEN) is an approved BCl-2 inhibitor for the treatment of chronic …
Development and Validation of a Simple HPLC–UV‐Based Bioanalytical Method for Estimation of Acalabrutinib in Rat Plasma and Its Application in Evaluation of …
ABSTRACT A robust and reproducible HPLC–UV‐based bioanalytical method for
acalabrutinib (ACP) was developed and validated in rat plasma using prednisone as …
acalabrutinib (ACP) was developed and validated in rat plasma using prednisone as …
Recent progress in therapeutic strategies and biomimetic nanomedicines based on neutrophils for inflammation treatment
Inflammation is a defensive response that helps repair and restore damaged tissue by
activating immune and nonimmune cells against pathogens. However, inflammation may …
activating immune and nonimmune cells against pathogens. However, inflammation may …
[HTML][HTML] Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics
Despite the safety and convenience of oral administration, poorly water-soluble drugs
compromise absorption and bioavailability. These drugs can exhibit low dissolution rates …
compromise absorption and bioavailability. These drugs can exhibit low dissolution rates …
Enteral Route Nanomedicine for Cancer Therapy
LZ Zhang, RJ Du, D Wang, J Qin, C Yu… - International Journal …, 2024 - Taylor & Francis
With the in-depth knowledge of the pathological and physiological characteristics of the
intestinal barrier–portal vein/intestinal lymphatic vessels–systemic circulation axis, oral …
intestinal barrier–portal vein/intestinal lymphatic vessels–systemic circulation axis, oral …
Venetoclax-Related Neutropenia in Leukemic Patients: A Comprehensive Review of the Underlying Causes, Risk Factors, and Management
LG Di Pasqua, MM Abdallah, F Feletti, M Vairetti… - Pharmaceuticals, 2024 - mdpi.com
Venetoclax is a Bcl-2 homology domain 3 (BH3) mimetic currently approved for the
treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) that has …
treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) that has …
Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
AYR Aziz, U Mahfufah, NA Syahirah, Habibie… - Drug Delivery and …, 2024 - Springer
Fluconazole (FLZ) has been widely used in the treatment of infection caused by Candida
albicans, including the treatment of vulvovaginal candidiasis (VVC). However, when …
albicans, including the treatment of vulvovaginal candidiasis (VVC). However, when …