Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

The composition of the gut microbiota and excessive ingestion of high‐fat diets (HFD) are
considered to be important factors for development of obesity. In this review we describe a …

Triglycerides are exclusively transported with chylomicrons and this process is critically
dependent on MTP. In addition to chylomicrons, absorption of phospholipids, free …

Triacylglycerols (triglycerides)(TGs) are the major storage molecules of metabolic energy
and FAs in most living organisms. Excessive accumulation of TGs, however, is associated …

Our knowledge of the uptake and transport of dietary fat and fat-soluble vitamins has
advanced considerably. Researchers have identified several new mechanisms by which …

Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with
metabolic syndrome, hypertension and diabetes. Although progress has been made, the …

Nutrient digestion and absorption is necessary for the survival of living organisms and has
evolved into the complex and specific task of the gastrointestinal (GI) system. While most …

Dietary fats and oils are an important component of our diet and a significant contributor to
total energy and intake of lipophilic nutrients and bioactives. We discuss their fate in a wide …