The production and use of antibiotics are becoming increasingly common worldwide, and
the problem of antibiotic resistance is increasing alarmingly. Drug‐resistant infections …

Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Antibiotic resistance, prompted by the overuse of antimicrobial agents, may arise from a
variety of mechanisms, particularly horizontal gene transfer of virulence and antibiotic …

Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed
interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis …

N-methylamine functionalities are valuable motifs, which play vital roles in the properties
and activities of essential fine and bulk chemicals including molecules used in life science …

Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1), a vital enzyme for cell wall
synthesis, plays a crucial role in the formation of lipoarabinomannan and arabinogalactan. It …

Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

Background: Antimicrobial resistance (AMR) has posed a serious threat to global public
health and it requires immediate action, preferably long term. Current drug therapies have …

Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Eighty years after the introduction of the first antituberculosis (TB) drug, the treatment of drug-
susceptible TB remains very cumbersome, requiring the use of four drugs (isoniazid …