Within the limited antifungal armamentarium, the azole antifungals are the most frequent
class used to treat Candida infections. Azole antifungals such as fluconazole are often …

Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

The role of sterol mutations in the resistance of Candida albicans to antifungal agents has
not been thoroughly investigated. Previous work reported that clinical C. albicans strains …

The burden of human disease associated with fungal infections is generally
underappreciated, with estimates indicating as many as 150 million persons infected …

The Tet repressor protein (TetR) regulates transcription of a family of tetracycline (tc)
resistance determinants in Gram‐negative bacteria. The resistance protein TetA, a …

Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in
humans, causing severe and often fatal invasive infections in immunocompromised patients …

Recent progress in medical sciences and therapy resulted in an increased number of
immunocompromised individuals. Candida albicans is the leading opportunistic fungal …

Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

One potentially rich source of possible targets for antifungal therapy are those Candida
albicans genes deemed essential for growth under the standard culture (ie, in vitro) …

Candida infections have increased due to the growth and expansion of susceptible patient
populations. The azole fluconazole is the most widely prescribed antifungal, but rising rates …