Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Conspectus The radical-mediated C–H functionalization of pyridines has attracted
considerable attention as a powerful tool in synthetic chemistry for the direct …

As the “chemical chameleon”, sulfonyl-containing compounds and their variants have been
merged with various types of reactions for the efficient construction of diverse molecular …

We report herein a modular class of organic catalysts that, acting as donors, can readily form
photoactive electron donor–acceptor (EDA) complexes with a variety of radical precursors …

Reactions that involve the addition of carbon‐centered radicals to basic heteroarenes,
followed by formal hydrogen atom loss, have become widely known as Minisci‐type …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

Carbon-hydrogen (C− H) functionalization of pyridines is a powerful tool for the rapid
construction and derivatization of many agrochemicals, pharmaceuticals, and materials …

This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

Basic heteroarenes are a ubiquitous feature of pharmaceuticals and bioactive molecules,
and Minisci-type additions of radical nucleophiles are a leading method for their elaboration …