The trace element zinc is required for proper functioning of a large number of proteins,
including various enzymes. However, most zinc-containing proteins are transcription factors …

Publisher Summary This chapter reviews the effects of alcohols on microorganisms.
Alcohols are ubiquitous small molecules, which are produced both chemically and as …

Background Ergosterol has been considered the “fungal sterol” for almost 125 years;
however, additional sterol data superimposed on a recent molecular phylogeny of kingdom …

Proton and/or sodium electrochemical gradients are critical to energy handling at the plasma
membranes of all living cells. Sodium gradients are used for animal plasma membranes, all …

The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …

Analyses with a yeast sterol auxotroph indicated that there are at least four different levels of
function for sterol which have been designated sparking, critical domain, domain and bulk …

Publisher Summary This chapter discusses the structure and function of sterols in fungi. The
distribution of sterols among fungi follows the taxonomic separation of fungi at the …

Considerable progress has been made in the selection and characterization of mutants that
are defective in the synthesis of ergosterol in the yeast, Saccharomyces cerevisiae …

We report the cloning, characterization, and overexpression of Saccharomyces cerevisiae
ERG7, which encodes lanosterol synthase [(S)-2, 3-epoxysqualene mutase (cyclizing …

Sterols and their derivatives promote and maintain growth and development in plants and
fungi by acting as membrane constituents and probably also as hormones, engaged in …