Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

Drug-resistant epilepsy: definition, pathophysiology, and management

B Mesraoua, F Brigo, S Lattanzi, B Abou-Khalil… - Journal of the …, 2023 - Elsevier
There are currently> 51 million people with epilepsy (PWE) in the world and every year> 4.9
million people develop new-onset epilepsy. The cornerstone of treatment in PWE is drug …

Predicting seizure recurrence after an initial seizure-like episode from routine clinical notes using large language models: a retrospective cohort study

BK Beaulieu-Jones, MF Villamar, P Scordis… - The Lancet Digital …, 2023 - thelancet.com
Background The evaluation and management of first-time seizure-like events in children can
be difficult because these episodes are not always directly observed and might be epileptic …

Revisiting the concept of drug‐resistant epilepsy: a TASK1 report of the ILAE/AES Joint Translational Task Force

S Auvin, AS Galanopoulou, SL Moshé, H Potschka… - …, 2023 - Wiley Online Library
Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …

The pharmacological treatment of epilepsy in adults

T Tomson, J Zelano, YL Dang, P Perucca - Epileptic Disorders, 2023 - Wiley Online Library
The pharmacological treatment of epilepsy entails several critical decisions that need to be
based on an individual careful risk–benefit analysis. These include when to initiate treatment …

Epilepsy with generalized tonic–clonic seizures alone: electroclinical features and prognostic patterns

E Cerulli Irelli, J Gesche, S Schlabitz, F Fortunato… - …, 2024 - Wiley Online Library
Objective Epilepsy with generalized tonic–clonic seizures alone (GTCA) is a common but
poorly characterized idiopathic generalized epilepsy (IGE) syndrome. Hence, we …

Levetiracetam vs lamotrigine as first-line antiseizure medication in female patients with idiopathic generalized epilepsy

EC Irelli, E Cocchi, A Morano, J Gesche… - JAMA …, 2023 - jamanetwork.com
Importance After the recent limitations to prescribing valproate, many studies have
highlighted the challenging management of female patients of reproductive age with …

Epilepsy classification using artificial intelligence: A web‐based application

AA Asadi‐Pooya, D Fattahi, N Abolpour… - Epilepsia …, 2023 - Wiley Online Library
Objective The purpose of the current endeavor was to evaluate the feasibility of using easily
accessible and applicable clinical information (based on history taking and physical …

Sex‐based electroclinical differences and prognostic factors in epilepsy with eyelid myoclonia

E Cerulli Irelli, E Cocchi, G Ramantani, A Morano… - …, 2023 - Wiley Online Library
Although a striking female preponderance has been consistently reported in epilepsy with
eyelid myoclonia (EEM), no study has specifically explored the variability of clinical …

Predictive models of epilepsy outcomes

S Sheikh, L Jehi - Current Opinion in Neurology, 2024 - journals.lww.com
Good to excellent predictive models are now available to guide medical and surgical
epilepsy decision-making with nomograms offering individualized predictions and user …