Effects of arachidonic acid metabolites on cardiovascular health and disease
Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …
The prostanoid EP4 receptor and its signaling pathway
U Yokoyama, K Iwatsubo, M Umemura, T Fujita… - Pharmacological …, 2013 - ASPET
The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …
Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms
Intracranial aneurysms are common but are generally untreated, and their rupture can lead
to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid …
to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid …
Pharmacologic management of aneurysms
JH Lindeman, JS Matsumura - Circulation research, 2019 - Am Heart Assoc
Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …
of larger aneurysms. Great potential exists for successful medical therapy that halts or …
Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male …
JL Allen, X Liu, S Pelkowski, B Palmer… - Environmental …, 2014 - ehp.niehs.nih.gov
Background: Air pollution has been associated with adverse neurological and behavioral
health effects in children and adults. Recent studies link air pollutant exposure to adverse …
health effects in children and adults. Recent studies link air pollutant exposure to adverse …
[HTML][HTML] E-type prostanoid receptor 4 (EP4) in disease and therapy
V Konya, G Marsche, R Schuligoi… - Pharmacology & …, 2013 - Elsevier
The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …
VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure
H Xu, S Du, B Fang, C Li, X Jia… - Proceedings of the …, 2019 - National Acad Sciences
Prostaglandin E2 (PGE2) plays an important role in vascular homeostasis. Its receptor, E-
prostanoid receptor 4 (EP4) is essential for physiological remodeling of the ductus arteriosus …
prostanoid receptor 4 (EP4) is essential for physiological remodeling of the ductus arteriosus …
Novel pharmacological approaches in abdominal aortic aneurysm
L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …
issue with an unmet medical need for therapy. This disease is featured by a progressive …
Oxidative stress and abdominal aortic aneurysm: potential treatment targets
Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key
mechanism implicated in AAA pathogenesis is inflammation and the associated production …
mechanism implicated in AAA pathogenesis is inflammation and the associated production …
Pharmacological therapy of abdominal aortic aneurysm: an update
Y Wang, Z Liu, J Ren, M Xiang - Current vascular …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic
dilation, is associated with high mortality. AAA is characterized by inflammation, smooth …
dilation, is associated with high mortality. AAA is characterized by inflammation, smooth …