Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

Patients with cancer with liver metastasis demonstrate significantly worse outcomes than
those without liver metastasis when treated with anti–PD-1 immunotherapy. The mechanism …

Application of cancer vaccines is limited due to their systemic immunotoxicity and inability to
satisfy all the steps, including loading of tumor antigens, draining of antigens to lymph nodes …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

Autoimmune diseases are a group of serious immune system disorders that are usually
idiopathic and persistent. Currently, autoimmune diseases are often diagnosed after obvious …

Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+ T
cells into T regulatory type 1 (TR1) cells, a subset of interleukin-10-producing Treg cells that …

Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Autoimmune disease is a chronic inflammatory disease caused by disorders of immune
regulation. Antigen-specific immunotherapy has the potential to inhibit the autoreactivity of …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …