Obesity, fat mass and immune system: role for leptin

V Francisco, J Pino, V Campos-Cabaleiro… - Frontiers in …, 2018 - frontiersin.org
Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

Leptin resistance: underlying mechanisms and diagnosis

O Gruzdeva, D Borodkina, E Uchasova… - … syndrome and obesity …, 2019 - Taylor & Francis
Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …

Exercise for prevention and relief of cardiovascular disease: prognoses, mechanisms, and approaches

D Tian, J Meng - Oxidative Medicine and Cellular Longevity, 2019 - Wiley Online Library
This review is aimed at summarizing the new findings about the multiple benefits of exercise
on cardiovascular disease (CVD). We pay attention to the prevalence and risk factors of …

Amylin: pharmacology, physiology, and clinical potential

DL Hay, S Chen, TA Lutz, DG Parkes, JD Roth… - Pharmacological …, 2015 - Elsevier
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

Adipose tissue, obesity and adipokines: role in cancer promotion

A Booth, A Magnuson, J Fouts… - … molecular biology and …, 2015 - degruyter.com
Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles.
Adipose depots have been characterized to release several adipocytokines that work locally …

Adipokines and non-alcoholic fatty liver disease: multiple interactions

TE Adolph, C Grander, F Grabherr, H Tilg - International journal of …, 2017 - mdpi.com
Accumulating evidence links obesity with low-grade inflammation which may originate from
adipose tissue that secretes a plethora of pro-and anti-inflammatory cytokines termed …

Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases

V Francisco, C Ruiz-Fernández, J Pino, A Mera… - Biochemical …, 2019 - Elsevier
Metabolic syndrome (MetS) represents a cluster of metabolic and cardiovascular
complications, including obesity and visceral adiposity, insulin resistance, dyslipidemia …

Obesity and its impact on COVID-19

AJM de Leeuw, MAM Oude Luttikhuis… - Journal of Molecular …, 2021 - Springer
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven
a challenge to healthcare systems since its first appearance in late 2019. The global spread …

[HTML][HTML] Estrogen: the necessary evil for human health, and ways to tame it

S Patel, A Homaei, AB Raju, BR Meher - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum,
tropism, tissue-specific distribution, and receptor affinity varies with different phases of life …

[HTML][HTML] The glucoregulatory actions of leptin

AM D'souza, UH Neumann, MM Glavas, TJ Kieffer - Molecular metabolism, 2017 - Elsevier
Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …