Overview: Long-term survival of T lymphocytes in quiescent state is essential to maintain
their cell numbers in secondary lymphoid organs and in peripheral circulation. In the …

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy characterized by
the clonal proliferation of immature T-cell precursors. T-ALL has many similar …

The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes
and is used to study non-MHC loci contributing to Type 1 diabetes. Type 1 diabetes in the …

The ability of glucocorticoids (GCs) to kill lymphoid cells led to their inclusion in essentially
all chemotherapy protocols for lymphoid malignancies, particularly childhood acute …

The IAN (immune-associated nucleotide-binding protein) family is a family of functionally
uncharacterized GTP-binding proteins expressed in vertebrate immune cells and in plant …

There is a growing family of novel GTPases conserved among higher plants and
vertebrates, abbreviated as AIG1, IAP, IMAP, and IAN, respectively. Here, we comparatively …

Abstract The human CD34+/CD38−/Lin− cell subset, comprising∼ 1–10% of the CD34+ cell
population, contains few of the less primitive hematopoietic (lineage-committed) progenitor …

We used a comprehensive collection of Affymetrix microarray datasets to ascertain which
genes or molecules distinguish the known major subsets of human T cells. Our strategy …

The life-or-death decision of immune cells makes an essential contribution to immune-
system development and the regulation of immune responses. A new family of cell-survival …

Gimap4, a member of the newly identified G TPase of the im munity-a ssociated p rotein
family (Gimap), is strongly induced by the pre–T-cell receptor in precursor T lymphocytes …