Dietary modifications for enhanced cancer therapy

N Kanarek, B Petrova, DM Sabatini - Nature, 2020 - nature.com
Tumours depend on nutrients supplied by the host for their growth and survival.
Modifications to the host's diet can change nutrient availability in the tumour …

Metabolic instruction of immunity

MD Buck, RT Sowell, SM Kaech, EL Pearce - Cell, 2017 - cell.com
Choices have consequences. Immune cells survey and migrate throughout the body and
sometimes take residence in niche environments with distinct communities of cells …

The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway

H Huang, D Zhang, Y Weng, K Delaney, Z Tang… - Science …, 2021 - science.org
Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular
signaling, in which lysine acetylation and methylation have been the historical focus of …

Quantitative fluxomics of circulating metabolites

S Hui, AJ Cowan, X Zeng, L Yang, T TeSlaa, X Li… - Cell metabolism, 2020 - cell.com
Mammalian organs are nourished by nutrients carried by the blood circulation. These
nutrients originate from diet and internal stores, and can undergo various interconversions …

Metabolic regulation of gene expression by histone lysine β-hydroxybutyrylation

Z Xie, D Zhang, D Chung, Z Tang, H Huang, L Dai, S Qi… - Molecular cell, 2016 - cell.com
Here we report the identification and verification of a β-hydroxybutyrate-derived protein
modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone …

Role of fatty acids in milk fat and the influence of selected factors on their variability—a review

O Hanuš, E Samková, L Křížová, L Hasoňová, R Kala - Molecules, 2018 - mdpi.com
Fatty acids (FAs) of milk fat are considered to be important nutritional components of the
diets of a significant portion of the human population and substantially affect human health …

Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer

CY Hwang, W Choe, KS Yoon, J Ha, SS Kim, EJ Yeo… - Nutrients, 2022 - mdpi.com
The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

M Lindefeldt, A Eng, H Darban, A Bjerkner… - npj Biofilms and …, 2019 - nature.com
The gut microbiota has been linked to various neurological disorders via the gut–brain axis.
Diet influences the composition of the gut microbiota. The ketogenic diet (KD) is a high-fat …

Metabolic reprogramming in cancer: Mechanisms and therapeutics

S Nong, X Han, Y Xiang, Y Qian, Y Wei, T Zhang… - MedComm, 2023 - Wiley Online Library
Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Ketogenic diet in cancer prevention and therapy: molecular targets and therapeutic opportunities

WH Talib, AI Mahmod, A Kamal, HM Rashid… - Current issues in …, 2021 - mdpi.com
Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …