Epithelial salt and water secretion serves a variety of functions in different organ systems,
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …

Sperm motility is linked to the activation of signaling pathways that trigger movement. These
pathways are mainly dependent on Ca2+, which acts as a secondary messenger. The …

Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …

Pendred syndrome is an autosomal recessive disorder that is classically defined by the
combination of sensorineural deafness/hearing impairment, goiter, and an abnormal …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

Summary Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl−
channels transiently activated by an increase in intracellular Ca2+. These channels are …

TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …

Abstract TMEM16A (ANO1) is a calcium-activated chloride channel (CaCC) expressed in
secretory epithelia, smooth muscle, and other tissues. Cell-based functional screening of∼ …

As a Ca 2+-activated lipid scramblase and ion channel that mediates Ca 2+ influx,
TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood …

Key Points• Chloride channels are important for proper hydration of the airway surface.•
TMEM16A protein is an important component of calcium‐activated chloride channels.• …