Artificial intelligence-driven advances in protein structure prediction in recent years have
raised the question: has the protein structure-prediction problem been solved? Here, with a …

T cells are essential immune cells responsible for identifying and eliminating pathogens.
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …

Neoepitopes arising from amino acid substitutions due to single nucleotide polymorphisms
are targets of T cell immune responses to cancer and are of significant interest in the …

Peptide‐based drugs offer high specificity, potency, and selectivity. However, their inherent
flexibility and differences in conformational preferences between their free and bound states …

Proteins are dynamic macromolecules that perform vital functions in cells. A protein structure
determines its function, but this structure is not static, as proteins change their conformation …

The identification of immunogenic peptides has become essential in an increasing number
of fields in immunology, ranging from tumor immunotherapy to vaccine development. The …

The precise prediction of major histocompatibility complex (MHC)-peptide complex
structures is pivotal for understanding cellular immune responses and advancing vaccine …

Identifying the interactome for a protein of interest is challenging due to the large number of
possible binders. High‐throughput experimental approaches narrow down possible binding …

The binding of peptides to class-I Major Histocompability Complex (MHC) receptors and
their subsequent recognition downstream by T-cell receptors are crucial processes for most …

Epitope mapping is a technique employed to define the region of an antigen that elicits an
immune response, providing crucial insight into the structural architecture of the antigen as …