A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness

H Choquet, RB Melles, J Yin, TJ Hoffmann… - Communications …, 2020 - nature.com
Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense
heritability estimates ranging between 0.68 to 0.95. Despite the high heritability and …

Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation

J Disatham, L Brennan, X Jiao, Z Ma… - Epigenetics & …, 2022 - Springer
Background Methylation at cytosines (mCG) is a well-known regulator of gene expression,
but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied …

Essential role of CRIM1 on endometrial receptivity in goat

D Yang, A Liu, Y Zhang, S Nan, R Yin, Q Lei… - International Journal of …, 2021 - mdpi.com
In domestic ruminants, endometrial receptivity is related to successful pregnancy and
economic efficiency. Despite several molecules having been reported in the past regarding …

A high-throughput assay for congenital and age-related eye diseases in zebrafish

LK Brastrom, CA Scott, DV Dawson, DC Slusarski - Biomedicines, 2019 - mdpi.com
Debilitating visual impairment caused by cataracts or microphthalmia is estimated to affect
roughly 20 million people in the United States alone. According to the National Eye Institute …

A novel role for CRIM1 in the corneal response to UV and pterygium development

E Maurizi, D Schiroli, SD Atkinson, L Mairs… - Experimental eye …, 2019 - Elsevier
Pterygium is a pathological proliferative condition of the ocular surface, characterised by
formation of a highly vascularised, fibrous tissue arising from the limbus that invades the …

[HTML][HTML] Heterozygous loss of Yap1 in mice causes progressive cataracts

Q Lu, Y Zhang, RB Kasetti, S Gaddipati… - … & Visual Science, 2020 - tvst.arvojournals.org
Purpose: Yap1 encodes an evolutionarily conserved transcriptional coactivator and
functions as a down-stream effector of the Hippo signaling pathway that controls tissue size …

[HTML][HTML] MiR-223 inhibits proliferation and steroid hormone synthesis of ovarian granulosa cell via the AKT signaling pathway by targeting CRIM1 in chicken

J Xiang, X Shen, Y Zhang, Q Zhu, H Yin, S Han - Poultry Science, 2024 - Elsevier
Within the poultry industry, hens' reproductive performance is of great economic
significance. The development and growth of follicles is a key aspect of hen egg production …

Eye lens organoids going simple: characterization of a new 3-dimensional organoid model for lens development and pathology

M Duot, R Viel, J Viet, C Le Goff-Gaillard, L Paillard… - bioRxiv, 2023 - biorxiv.org
The ocular lens, along with the cornea, focuses light on the retina to generate sharp images.
Opacification of the lens, or cataract, is the leading cause of blindness worldwide. Presently …

The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis

F Wazin, FJ Lovicu - Experimental Eye Research, 2020 - Elsevier
The transparent and refractive properties of the ocular lens are dependent on its precise
cellular structure, supported by the regulation of lens cellular processes of proliferation and …

[PDF][PDF] Amphibian and fish eye lens used as biomarker of remote and chronic environmental contamination

I Simakov, A Nikiforov-Nikishin… - Ecologica …, 2021 - researchgate.net
The lens of vertebrates has a general structural plan and reacts similarly to various factors of
anthropogenic impact. Rainbow trout (Oncorhynchus mykiss) and grass frog (Rana …