The angiotensin II type 2 receptor in cardiovascular disease

CA Lemarié, EL Schiffrin - Journal of the renin-angiotensin …, 2010 - journals.sagepub.com
Angiotensin II (Ang II) is considered the major final mediator of the renin-angiotensin system.
The actions of Ang II have been implicated in many cardiovascular conditions, such as …

Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin–angiotensin system

BI Lévy - Circulation, 2004 - Am Heart Assoc
ical states. This raises the important question of their function in the cardiovascular system
relative to that of AT1. The 2 receptor subtypes also appear to have different signaling …

Ischemia‐reperfusion selectively impairs nitric oxide‐mediated dilation in coronary arterioles: counteracting role of arginase

TW Hein, C Zhang, W Wang, CI Chang… - The FASEB …, 2003 - Wiley Online Library
ABSTRACT A reduction in L‐arginine availability has been implicated in the impairment of
endothelium‐dependent nitric oxide (NO)‐mediated vasodilation by ischemia‐reperfusion …

How to explain the differences between renin angiotensin system modulators

BI Levy - American journal of hypertension, 2005 - academic.oup.com
Abstract Angiotensin II (Ang II) plays important roles in the development of cardiovascular
diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart …

The Other Angiotensin II Receptor: AT2R as a Therapeutic Target

L Juillerat-Jeanneret - Journal of medicinal chemistry, 2020 - ACS Publications
The active hormone of the renin–angiotensin system (RAS), angiotensin II (Ang II), is
involved in several human diseases, driving the development and clinical use of several …

Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats

M Soga, FA Kamal, K Watanabe, M Ma… - International journal of …, 2006 - Elsevier
BACKGROUND: Daunorubicin is an anthracycline anti-tumor agent; anthracycline
chemotherapy in cancer can cause severe cardiomyopathy leading to a frequently fatal …

[HTML][HTML] Cell-specific protective signaling induced by the novel AT2R-agonist NP-6A4 on human endothelial and smooth muscle cells

R Toedebusch, A Belenchia, L Pulakat - Frontiers in Pharmacology, 2018 - frontiersin.org
Cardiovascular disease incidence continues to rise and new treatment paradigms are
warranted. We reported previously that activation of Angiotensin II receptor (encoded by the …

AT1R/GSK‐3β/mTOR Signaling Pathway Involved in Angiotensin II‐Induced Neuronal Apoptosis after HIE Both In Vitro and In Vivo

W Si, B Li, C Lenahan, S Li, R Gu, H Qu… - Oxidative medicine …, 2020 - Wiley Online Library
Objective. The focus of the present study is to evaluate the effects of Angiotensin II (Ang II)
on neuronal apoptosis after HIE and the potential underlying mechanisms. Methods. Primary …

Valsartan-induced cardioprotection involves angiotensin II type 2 receptor upregulation in dog and rat models of in vivo reperfused myocardial infarction

BI Jugdutt, V Menon - Journal of cardiac failure, 2004 - Elsevier
BACKGROUND: Cardioprotection with angiotensin II (AngII) type 1 receptor (AT1R)
blockade was associated with AngII type 2 receptor (AT2R) upregulation and activation …

Upregulation of angiotensin II type 2 receptor and limitation of myocardial stunning by angiotensin II type 1 receptor blockers during reperfused myocardial infarction in …

BI Jugdutt, V Menon - Journal of cardiovascular …, 2003 - journals.sagepub.com
Background: We have previously shown that angiotensin II type 1 receptor blockers induce
cardioprotection and upregulate angiotensin II type 2 receptor during in vivo …