Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Cerebrovascular diseases are pathological conditions involving impaired blood flow in the
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …

Revascularization treatment is a critical measure for tissue engineering therapies like spinal
cord repair. As multipotent stem cells, mesenchymal stem cells (MSCs) have proven to …

Background Ischemic stroke can induce changes in mitochondrial morphology and function.
As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the …

Palmatine (PAL), a natural isoquinoline alkaloid, possesses extensive biological and
pharmaceutical activities, including antioxidative stress, anti‐inflammatory, antitumor …

Excessive death of myocardial cells can lead to various cardiovascular diseases and even
develop into heart failure, so developing ideal treatment plans based on pathogenesis is of …

Stroke is the main cause of disability and death in the world within neurological diseases.
Despite such a huge impact, enzymatic, and mechanical recanalization are the only …

Neuroinflammation plays a strong part in cerebral ischemia-reperfusion injury, and
microglial activation is regarded as a marker for neuroinflammation. Long noncoding RNA …

Cerebral ischemia/reperfusion (I/R) injury contributes considerably to the poor prognosis in
patients with ischemic stroke. This study is aimed to delineate the molecular mechanistic …

Blood-brain barrier (BBB) integrity is essential to maintaining brain health. Aging-related
alterations could lead to chronic progressive leakiness of the BBB, which is directly …