The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the
maintenance of an array of physiological processes. The physical contact and association …

Natural products are small molecules naturally produced by multiple sources such as plants,
animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by …

Pel exopolysaccharide biosynthetic loci are phylogenetically widespread biofilm matrix
determinants in bacteria. In Pseudomonas aeruginosa, Pel is crucial for cell-to-cell …

Reactive oxygen species (ROS) are generated during normal metabolic processes under
aerobic conditions. Since ROS production initiates harmful radical chain reactions on …

In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …

The γ-aminobutyric acid–mediated (GABAergic) system participates in many aspects of
organismal physiology and disease, including proteostasis, neuronal dysfunction, and life …

Advances in the field of redox biology have contributed to the understanding of the
complexity of the thiol-based system in mediating signal transduction. The redox …

Exercise generates a site-specific increase in Reactive Oxygen Species (ROS) within
muscle that promotes changes in gene transcription and mitochondrial biogenesis, required …

Endogenous and exogenous stresses elicit transcriptional responses that limit damage and
promote cell/organismal survival. Like its mammalian counterparts, hepatocyte nuclear …

An accumulating body of evidence suggests that transient or physiological reactive oxygen
species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) …