Intravitreal administration is the method of choice in drug delivery to the retina and/or
choroid. Rabbit is the most commonly used animal species in intravitreal pharmacokinetics …

Monoclonal antibodies (mAbs) are an important therapeutic class with complex
pharmacology and interdependent pharmacokinetic (PK) and pharmacodynamics (PD) …

Protein therapeutics have drastically changed the landscape of treatment for many diseases
by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical …

Objective Here we provide a critical review of the state of the art with respect to non-clinical
assessments of immunogenicity for therapeutic proteins. Key findings The number of studies …

Purpose To review pharmacokinetic and pharmacodynamic characteristics of antibodies that
bind to soluble ligands within the framework of calcitonin gene-related peptide antibodies …

Monoclonal antibodies (mAbs) are currently the largest and most dominant class of
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …

Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is
important to ensure that all patients attain suitable drug exposure to achieve efficacy and …

Therapeutic protein products (TPPs) are of considerable value in the treatment of a variety of
diseases, including cancer, hemophilia, and autoimmune diseases. The success of TPP …

Biopharmaceuticals (BPs) represent a rapidly growing class of approved and investigational
drug therapies that is contributing significantly to advancing treatment in multiple disease …

Circulating antibodies that specifically bind polyethylene glycol (PEG), a polymer routinely
used in protein and nanoparticle therapeutics, have been associated with reduced efficacy …