DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

The interactions of various low-molecular weight substances with DNA are naturally relevant
mechanisms in the cellular cycle and so also used in medicinal treatment. Depending on the …

Revised Manuscript Received August 14, 1989 abstract: The anticancer drugs adriamycin
and daunomycin have each been crystallized with the DNA sequence d (CGATCG) and the …

The three-dimensional structure of a TATA-box binding polypeptide complexed with the
TATA element of the adenovirus major late promoter has been determined by X-ray …

The sequence-dependent structure of DNA is analysed on the basis of the energetics of the
base stacking (π-π) interactions. The conformational preferences of the ten possible base …

Two-dimensional NMR has been used to study the 2: 1 distamycin Ad (CGCAAATTGGC). d
(GCCAATTTGCG) complex. The nuclear Overhauser effect spectroscopy (NOESY) …

Despite DNA being an important target for several drugs, most of the docking programs are
validated only for proteins and their ligands. In this paper, we used AutoDock 4.0 to perform …

Revised Manuscript Received May 31, 1990 abstract; The interactions of DAPI with natural
DNA and synthetic polymers have been investigated by hydrodynamic, DNase Ifootprinting …

A computational method for exploring the orientational and conformational space of a
flexible ligand within a macromolecular receptor site is presented. The approach uses a …

The structure of the DNA fluorochrome 4′-6-diamidine-2-phenyl indole (DAPI) bound to the
synthetic B-DNA oligonucleotide CGCGAATTCGCG has been solved by single crystal x-ray …