Thrombus structural composition in cardiovascular disease

G Alkarithi, C Duval, Y Shi, FL Macrae… - … , and vascular biology, 2021 - Am Heart Assoc
Thrombosis is a major complication of cardiovascular disease, leading to myocardial
infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a …

Correlation of imaging and histopathology of thrombi in acute ischemic stroke with etiology and outcome: a systematic review

W Brinjikji, S Duffy, A Burrows, W Hacke… - Journal of …, 2017 - jnis.bmj.com
Background and purpose Studying the imaging and histopathologic characteristics of
thrombi in ischemic stroke could provide insights into stroke etiology and ideal treatment …

Stroke proteomics: from discovery to diagnostic and therapeutic applications

K Hochrainer, W Yang - Circulation research, 2022 - Am Heart Assoc
Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Insights from thrombi retrieved in stroke due to large vessel occlusion

M Bacigaluppi, A Semerano… - Journal of Cerebral …, 2019 - journals.sagepub.com
The recent advances of endovascular procedures to treat stroke due to large cerebral vessel
occlusion have made it possible to analyze the retrieved thrombus material. Analysis of …

Integrated analysis and exploration of potential shared gene signatures between carotid atherosclerosis and periodontitis

Y Zeng, S Cao, M Chen - BMC Medical Genomics, 2022 - Springer
Background Increasing evidence has suggested an association between carotid
atherosclerosis (CAS) and periodontitis (PD); however, the mechanisms have not been fully …

Potential biomarkers of acute ischemic stroke etiology revealed by mass spectrometry-based proteomic characterization of formalin-fixed paraffin-embedded blood …

R Rossi, OM Mereuta, M Barbachan e Silva… - Frontiers in …, 2022 - frontiersin.org
Background and Aims Besides the crucial role in the treatment of acute ischemic stroke
(AIS), mechanical thrombectomy represents a unique opportunity for researchers to study …

Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology

VM Tutino, S Fricano, A Chien, TR Patel… - Journal of …, 2023 - jnis.bmj.com
Background Determining stroke etiology is crucial for secondary prevention, but intensive
workups fail to classify~ 30% of strokes that are cryptogenic. Objective To examine the …

Bioinformatics gene analysis of potential biomarkers and therapeutic targets for unstable atherosclerotic plaque-related stroke

S Zhou, S Liu, X Liu, W Zhuang - Journal of Molecular Neuroscience, 2021 - Springer
Atherosclerotic plaque instability is a major cause of ischemic stroke. Researchers must
develop novel strategies for the detection and treatment of unstable atherosclerotic plaque …

Machine learning analysis of the cerebrovascular thrombi proteome in human ischemic stroke: an exploratory study

C Dargazanli, E Zub, J Deverdun… - Frontiers in …, 2020 - frontiersin.org
Objective: Mechanical retrieval of thrombotic material from acute ischemic stroke patients
provides a unique entry point for translational research investigations. Here, we resolved the …

Advancing Stroke Research on Cerebral Thrombi with Omic Technologies

G Costamagna, S Bonato, S Corti… - International Journal of …, 2023 - mdpi.com
Cerebrovascular diseases represent a leading cause of disability, morbidity, and death
worldwide. In the last decade, the advances in endovascular procedures have not only …