Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology
Identification of Lgr5 as the intestinal stem cell marker as well as the growth factors
necessary to replicate adult intestinal stem cell division has led to the establishment of the …
necessary to replicate adult intestinal stem cell division has led to the establishment of the …
Organoid based personalized medicine: from bench to bedside
Y Li, P Tang, S Cai, J Peng, G Hua - Cell Regeneration, 2020 - Springer
Three-dimensional cultured organoids have become a powerful in vitro research tool that
preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be …
preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be …
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …
in the lungs in the setting of an overzealous immune response whose origin remains …
[HTML][HTML] A high-throughput organoid microinjection platform to study gastrointestinal microbiota and luminal physiology
IA Williamson, JW Arnold, LA Samsa, L Gaynor… - Cellular and molecular …, 2018 - Elsevier
Background & Aims The human gut microbiota is becoming increasingly recognized as a
key factor in homeostasis and disease. The lack of physiologically relevant in vitro models to …
key factor in homeostasis and disease. The lack of physiologically relevant in vitro models to …
Bifidobacterium dentium fortifies the intestinal mucus layer via autophagy and calcium signaling pathways
MA Engevik, B Luk, AL Chang-Graham, A Hall… - MBio, 2019 - Am Soc Microbiol
Much remains unknown about how the intestinal microbiome interfaces with the protective
intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can …
intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can …
[HTML][HTML] Human-derived Bifidobacterium dentium modulates the mammalian serotonergic system and gut–brain axis
MA Engevik, B Luck, C Visuthranukul… - Cellular and molecular …, 2021 - Elsevier
Background & Aims The human gut microbiota can regulate production of serotonin (5-
hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms …
hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms …
Microbial metabolic capacity for intestinal folate production and modulation of host folate receptors
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human
health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin …
health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin …
Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors
The gut microbiome is extremely important for maintaining homeostasis with host intestinal
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …
Modeling host-pathogen interactions in the context of the microenvironment: three-dimensional cell culture comes of age
Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …
microbial pathogens and commensals function to regulate health and disease. While flat two …
Organoid culture systems to study host–pathogen interactions
Highlights•Organoids are excellent platforms to discover measures against emerging
pathogens.•Organoid models of ZIKV, C. difficle, and H. pylori infection have been …
pathogens.•Organoid models of ZIKV, C. difficle, and H. pylori infection have been …