In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

The Golgi functions principally in the biogenesis and trafficking of glycoproteins and lipids. It
is compartmentalized into multiple flattened adherent membrane sacs termed cisternae …

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we
identified a chromosome 3q amplicon that serves as a platform for secretory regulation in …

Insulin is synthesized by pancreatic β-cells and stored into secretory granules (SGs). SGs
fuse with the plasma membrane in response to a stimulus and deliver insulin to the …

Eukaryotic cells contain dynamic membrane-bound organelles that are constantly
remodeled in response to physiological and environmental cues. Key organelles are the …

Biosynthetic sorting of newly synthesized transmembrane cargos to endosomes and
lysosomes is thought to occur at the TGN through recognition of sorting signals in the …

How the principal functions of the Golgi apparatus—protein processing, lipid synthesis, and
sorting of macromolecules—are integrated to constitute cargo-specific trafficking pathways …

The sorting of secreted cargo proteins and their export from the trans-Golgi network (TGN)
remains an enigma in the field of membrane trafficking; although the sorting mechanisms of …

Constitutive vesicle trafficking is the default pathway used by all cells for movement of
intracellular cargoes between subcellular compartments and in and out of the cell …

Calcium ions (Ca2+) are prominent cell signaling effectors that regulate a wide variety of
cellular processes. Among the different players in Ca2+ homeostasis, primary active Ca2+ …