40 years of IGF1: IGF-binding proteins
LA Bach - Journal of molecular endocrinology, 2018 - jme.bioscientifica.com
Insulin-like growth factor-binding proteins (IGFBPs) 1–6 bind IGFs but not insulin with high
affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions …
affinity. They were initially identified as serum carriers and passive inhibitors of IGF actions …
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts
F Mollinedo, C Gajate - Journal of lipid research, 2020 - ASBMB
Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
play a critical role in the compartmentalization of signaling pathways. Physical segregation …
[HTML][HTML] The insulin receptor and its signal transduction network
P De Meyts - Endotext [Internet], 2016 - ncbi.nlm.nih.gov
Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting
through a receptor located in the membrane of target cells-major ones being liver (where it …
through a receptor located in the membrane of target cells-major ones being liver (where it …
Therapeutic targeting of the IGF axis
E Osher, VM Macaulay - Cells, 2019 - mdpi.com
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …
development, and when deregulated makes an important contribution to disease. Here, we …
Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions
Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
Growth hormone, insulin-like growth factors, and the skeleton
A Giustina, G Mazziotti, E Canalis - Endocrine reviews, 2008 - academic.oup.com
Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …
achievement of normal longitudinal bone growth and bone mass. Although GH may act …
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
AW Burgess, HS Cho, C Eigenbrot, KM Ferguson… - Molecular cell, 2003 - cell.com
Recent crystallographic studies have provided significant new insight into how receptor
tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor …
tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor …
Structural basis of the activation of type 1 insulin-like growth factor receptor
Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates
cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we …
cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we …
Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors
The insulin superfamily of peptides is essential for homeostasis as well as neuronal
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …