Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform
In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
Three-dimensional in vitro cell culture models for efficient drug discovery: Progress so far and future prospects
Despite tremendous advancements in technologies and resources, drug discovery still
remains a tedious and expensive process. Though most cells are cultured using 2D …
remains a tedious and expensive process. Though most cells are cultured using 2D …
Three‐dimensional cell culture models for anticancer drug screening: Worth the effort?
ET Verjans, J Doijen, W Luyten… - Journal of cellular …, 2018 - Wiley Online Library
High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …
predictive capacity of artificial monolayer cell culture assays early in drug discovery …
Advances in organ-on-a-chip materials and devices
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …
based chemical and biological sensors: Engineering aspects
S Ahmed, MPN Bui, A Abbas - Biosensors and Bioelectronics, 2016 - Elsevier
Remarkable efforts have been dedicated to paper-based chemosensors and biosensors
over the last few years, mainly driven by the promise of reaching the best trade-off between …
over the last few years, mainly driven by the promise of reaching the best trade-off between …
In vitro 3D cultures to model the tumor microenvironment
F Fontana, M Marzagalli, M Sommariva, N Gagliano… - Cancers, 2021 - mdpi.com
Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …
3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
JL Albritton, JS Miller - Disease models & mechanisms, 2017 - journals.biologists.com
Even with many advances in treatment over the past decades, cancer still remains a leading
cause of death worldwide. Despite the recognized relationship between metastasis and …
cause of death worldwide. Despite the recognized relationship between metastasis and …