The excessive production of IL-10, an anti-inflammatory cytokine, by Leishmania antigen-
activated T cells is supposed to be a key player in the onset and progression of visceral …

Introduction Cerebral malaria (CM) is a lethal neuroinflammatory disease caused by
Plasmodium infection. Immune cells and brain parenchyma cells contribute to the …

One of the recent challenges in the design/development of prosthetic orthopedic implants is
to address the concern of local/systemic toxicity of debris particles, released due to wear or …

CD8+ T cells are an important regiment of adaptive immunity that play a decisive role in
elimination of many species of Leishmania parasite from the host. In visceral leishmaniasis …

Background Gnathostomiasis is an important zoonosis in tropical areas that is mainly
caused by third-stage Gnathostoma spinigerum larvae (G. spinigerum L3). Objectives This …

CD300a is differentially expressed among B cell subsets, although its expression in
immunoglobulin (Ig) M+ B cells is not well known. We identified a B cell subset expressing …

Parasitic infections are a major public health concern affecting millions globally. Antibiotic
resistance makes it hard to treat these diseases, and climate change exacerbates the …

One of the major reasons behind the limited success of vaccine candidates against all forms
of leishmaniasis is the inability of parasitic antigens to induce robust cell-mediated immunity …

Paragonimiasis (pulmonary fluke disease) is a foodborne parasitic disease caused by
trematode infections. Paragonimus proliferus is a characteristic Paragonimus species that …

However, the pharmaceutical industry is still not as interested in developing drugs for the
treatment of parasitic infections as in other drugs. Even antiparasitic drugs discovered at the …