Cortical interneurons display striking differences in shape, physiology, and other attributes,
challenging us to appropriately classify them. We previously suggested that interneuron …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its …

INTRODUCTION What determines the pace of embryonic development? Although the
molecular and cellular mechanisms of many developmental processes are evolutionarily …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Spinal cord neural stem cells (NSCs) have great potential to reconstitute damaged spinal
neural circuitry, but they have yet to be generated in vitro. We now report the derivation of …

A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

From the beginning, induced pluripotent stem cell (iPSC) technology was touted as a path to
improve our understanding of disease biology and enable drug discovery. Advances in …

Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …