Mitochondrial VDAC1: A potential therapeutic target of inflammation-related diseases and clinical opportunities

H Hu, L Guo, J Overholser, X Wang - Cells, 2022 - mdpi.com
The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

Alpha-synuclein and mitochondrial dysfunction in Parkinson's disease: the emerging role of VDAC

P Risiglione, F Zinghirino, MC Di Rosa, A Magrì… - Biomolecules, 2021 - mdpi.com
Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in
modulation of mitochondrial function in both physiological and pathological conditions …

High-Resolution Respirometry Reveals MPP+ Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson's Disease

P Risiglione, L Leggio, SAM Cubisino, S Reina… - International journal of …, 2020 - mdpi.com
MPP+ is the active metabolite of MPTP, a molecule structurally similar to the herbicide
Paraquat, known to injure the dopaminergic neurons of the nigrostriatal system in …

[HTML][HTML] Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress

S Reina, SC Nibali, MF Tomasello, A Magrì, A Messina… - Redox biology, 2022 - Elsevier
Unraveling the role of VDAC3 within living cells is challenging and still requires a definitive
answer. Unlike VDAC1 and VDAC2, the outer mitochondrial membrane porin 3 exhibits …

Renaissance of VDAC: new insights on a protein family at the interface between mitochondria and cytosol

V De Pinto - Biomolecules, 2021 - mdpi.com
It has become impossible to review all the existing literature on Voltage-Dependent Anion
selective Channel (VDAC) in a single article. A real Renaissance of studies brings this …

VDAC1 knockout affects mitochondrial oxygen consumption triggering a rearrangement of ETC by impacting on complex I activity

A Magrì, SAM Cubisino, G Battiato, CLR Lipari… - International Journal of …, 2023 - mdpi.com
Voltage-Dependent Anion-selective Channel isoform 1 (VDAC1) is the most abundant
isoform of the outer mitochondrial membrane (OMM) porins and the principal gate for ions …

Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules

H Gorny, A Mularoni, JG Delcros, C Freton… - Journal of enzyme …, 2023 - Taylor & Francis
The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in
metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless …

Pan‐Cancer Analysis of Voltage‐Dependent Anion Channel (VDAC1) as a Cancer Therapeutic Target or Diagnostic Biomarker

Z Wang, Y Cheng, Z Song, R Zhao - Disease Markers, 2022 - Wiley Online Library
The voltage‐dependent anion channel 1 (VDAC1), a pore protein located in the outer
mitochondrial membrane, has been confirmed to be related to cancer in cell or animal …

Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance

P Jóźwiak, P Ciesielski, E Forma, K Kozal… - Tumor …, 2020 - journals.sagepub.com
The exchange of metabolites between mitochondria and cytosol occurs through pores
formed by voltage-dependent anion channel proteins. Voltage-dependent anion channels …

Porins as helpers in mitochondrial protein translocation

A Grevel, T Becker - Biological chemistry, 2020 - degruyter.com
Mitochondria import the vast majority of their proteins via dedicated protein machineries. The
translocase of the outer membrane (TOM complex) forms the main entry site for precursor …