A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …

Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

Functional genomics data has the potential to increase GWAS power by identifying SNPs
that have a higher prior probability of association. Here, we introduce a method that …

Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human
complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability …

Genome-wide association studies (GWAS) have identified over 100 risk loci for
schizophrenia, but the causal mechanisms remain largely unknown. We performed a …

Genetic factors contribute importantly to the risk of coronary artery disease (CAD), and in the
past decade, there has been major progress in this area. The tools applied include genome …

Coronary artery disease represents the leading cause of death worldwide, sparing no
nation, ethnicity, or economic stratum. Coronary artery disease is partly heritable. While …

Rationale: Genome-wide association studies have identified hundreds of loci associated
with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory …

Background: There is considerable interest in whether genetic data can be used to improve
standard cardiovascular disease risk calculators, as the latter are routinely used in clinical …

Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …