Explainable artificial intelligence applications in cyber security: State-of-the-art in research
This survey presents a comprehensive review of current literature on Explainable Artificial
Intelligence (XAI) methods for cyber security applications. Due to the rapid development of …
Intelligence (XAI) methods for cyber security applications. Due to the rapid development of …
Immune biology of glioma-associated macrophages and microglia: functional and therapeutic implications
CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …
microglia, which are the innate immune sentinels and frontline host immune barriers against …
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …
Chinese Glioma Genome Atlas (CGGA): a comprehensive resource with functional genomic data from Chinese glioma patients
Gliomas are the most common and malignant intracranial tumors in adults. Recent studies
have revealed the significance of functional genomics for glioma pathophysiological studies …
have revealed the significance of functional genomics for glioma pathophysiological studies …
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …
ALKBH5 facilitates hypoxia-induced paraspeckle assembly and IL8 secretion to generate an immunosuppressive tumor microenvironment
The dynamic changes of RNA N6-methyl-adenosine (m6A) during cancer progression
contribute to quick adaption to microenvironmental changes. Here, we profiled the cancer …
contribute to quick adaption to microenvironmental changes. Here, we profiled the cancer …
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas
The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are
poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single …
poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single …
Targeting the Siglec–sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma
Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective
therapies are urgently needed. Cancer cells are capable of evading clearance by …
therapies are urgently needed. Cancer cells are capable of evading clearance by …
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
Cancer stem cells are critical for cancer initiation, development, and treatment resistance.
Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is …
Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is …