The natural killer (NK)-cell immunological synapse is the dynamic interface formed between
an NK cell and its target cell. Formation of the NK-cell immunological synapse involves …

Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune
synapse in discrete regulated steps, which give rise to an extensive array of cellular …

Trogocytosis modulates immune responses, with still unclear underlying molecular
mechanisms. Using leukemia mouse models, we found that lymphocytes perform …

Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have
revolutionized treatment for several cancer types over the past decade. Despite this success …

Membrane nanotubes are transient long-distance connections between cells that can
facilitate intercellular communication (for example, by trafficking vesicles or transmitting …

Over the last decade, our understanding of the physiological role of senescent cells has
drastically evolved, from merely indicators of cellular stress and ageing to having a central …

The interaction of noncytotoxic decidual natural killer cells (dNK) and extravillous
trophoblasts (EVT) at the maternal–fetal interface was studied. Confocal microscopy …

Natural killer (NK) cells have long been known to mediate anti-tumor responses without prior
sensitization or recognition of specific tumor antigens. However, the tumor microenvironment …

Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells.
However, in stress conditions, more robust mechanisms might be necessary to facilitate cell …

NKG2D plays a major role in controlling immune responses through the regulation of natural
killer (NK) cells, αβ and γδ T-cell function. This activating receptor recognizes eight distinct …