A systematic review of the pharmacology, toxicology and pharmacokinetics of matrine

L You, C Yang, Y Du, W Wang, M Sun, J Liu… - Frontiers in …, 2020 - frontiersin.org
Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs,
such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests …

Research progress on the pharmacological effects of matrine

Y Sun, L Xu, Q Cai, M Wang, X Wang… - Frontiers in …, 2022 - frontiersin.org
Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic
asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action …

Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin

W Liu, Q Feng, Y Li, L Ye, M Hu, Z Liu - Toxicology and applied …, 2012 - Elsevier
Emodin is a poorly bioavailable but promising plant-derived anticancer drug candidate. The
low oral bioavailability of emodin is due to its extensive glucuronidation in the intestine and …

Sustained release of co-amorphous matrine-type alkaloids and resveratrol with anti-COVID-19 potential

D Hu, X Chen, D Li, H Zhang, Y Duan, Y Huang - Pharmaceutics, 2022 - mdpi.com
Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with
varying biological activities; matrine was recently used for the treatment of coronavirus …

Bioactivity and bioavailability of ginsenosides are dependent on the glycosidase activities of the A/J mouse intestinal microbiome defined by pyrosequencing

T Niu, DL Smith, Z Yang, S Gao, T Yin, ZH Jiang… - Pharmaceutical …, 2013 - Springer
Purpose To investigate the ability of bacteria in the intestinal microbiome to convert naturally
occurring primary ginsenosides in red ginseng extract to active secondary ginsenosides …

Investigating herb–herb interactions: The potential attenuated toxicity mechanism of the combined use of Glycyrrhizae radix et rhizoma (Gancao) and Sophorae …

L Shi, X Tang, X Dang, Q Wang, X Wang, P He… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Glycyrrhizae radix et rhizoma (Gancao) is often prescribed
together with Sophorae flavescentis radix (Kushen) in traditional Chinese medicinal practice …

A comprehensive review on pharmacokinetic profile of some traditional Chinese medicines

P Mehta, V Dhapte - New Journal of Science, 2016 - Wiley Online Library
Herbal medicines are the oldest and most widely used form of treatment for welfare of
mankind. Herbal medicines possess strong reputation as complementary treatment across …

Matrine directly activates extracellular heat shock protein 90, resulting in axonal growth and functional recovery in spinal cord injured-mice

N Tanabe, T Kuboyama, C Tohda - Frontiers in Pharmacology, 2018 - frontiersin.org
After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an
inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as …

[PDF][PDF] A review of medicinal plants used in therapy of cardiovascular diseases

AH Mota - Int. J. Pharmacogn. Phytochem. Res, 2016 - researchgate.net
Phytochemicals are present in fruits and vegetables, it is important the consumption by the
effects in protection of cardiovascular diseases mainly because these diseases are the first …

[引用][C] Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora

Z Yang, JR Wang, T Niu, S Gao, T Yin, M You… - Drug Metabolism and …, 2012 - ASPET