Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …
[HTML][HTML] Molecular genetics of early-onset Alzheimer's disease revisited
R Cacace, K Sleegers, C Van Broeckhoven - Alzheimer's & dementia, 2016 - Elsevier
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
A hallmark of Alzheimer's disease (AD) is the aggregation of β-amyloid peptides (Aβ) into
amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the …
amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the …
Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
A century of Alzheimer's disease
M Goedert, MG Spillantini - science, 2006 - science.org
One hundred years ago a small group of psychiatrists described the abnormal protein
deposits in the brain that define the most common neurodegenerative diseases. Over the …
deposits in the brain that define the most common neurodegenerative diseases. Over the …
[HTML][HTML] Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …
biochemical dissection of β-amyloid in 1984, the" amyloid hypothesis" of Alzheimer's …
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions (both
cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 …
cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 …
Genetics of dementia
Summary 25% of all people aged 55 years and older have a family history of dementia. For
most, the family history is due to genetically complex disease, where many genetic …
most, the family history is due to genetically complex disease, where many genetic …
Genetic insights in Alzheimer's disease
K Bettens, K Sleegers, C Van Broeckhoven - The lancet neurology, 2013 - thelancet.com
In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-
gene-based association studies have been supplanted by exome sequencing, genome …
gene-based association studies have been supplanted by exome sequencing, genome …
The genetic epidemiology of neurodegenerative disease
Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous
system. In fact, it has been the very knowledge gained from genetic studies that has allowed …
system. In fact, it has been the very knowledge gained from genetic studies that has allowed …