Cardiovascular diseases (CVDs) are the major causes of mortality in persons with diabetes,
and many factors, including hypertension, contribute to this high prevalence of CVD …

Some 12 years ago, a polymorphism of the angiotensin I-converting enzyme (ACE) gene
became the first genetic element shown to impact substantially on human physical …

The renin-angiotensin system (RAS) may alter cardiac energy metabolism in heart failure.
Angiotensin II (ANG II), the main effector of the RAS in heart failure, has emerged as an …

The renin–angiotensin system (RAS) plays a key pathogenic role in heart failure. The
adverse effects of angiotensin II (Ang II), a major player of the RAS, contributes to the …

The disablement process is often accompanied by sarcopenia or muscle loss, which is
associated with virtually all identified disability risk factors. Clinically, the association …

The metabolic functionality of adipose tissue is intimately dependent on local
communication between various cell types. It influences not only the equilibrium between …

Background: Cerebral edema is an important initial event in cases of stroke among humans.
Although hypertension is a major risk factor for endothelial injury, the precise mechanisms …

This study was designed to test the effects of angiotensin-converting enzyme (ACE)
inhibition on body composition and physical performance in aged rats. Male Brown Norway× …

According to Fick's principle, any metabolic or hormonal exchange through a given tissue
depends on the product of the blood flow to that tissue and the arteriovenous difference. The …

The aim of this study was to determine whether acute dual angiotensin‐converting enzyme
(ACE)/neutral endopeptidase 24‐11 (NEP) inhibition could improve whole body insulin …