Pathogenic role of exosomes and microRNAs in HPV‐mediated inflammation and cervical cancer: a review

J Sadri Nahand, M Moghoofei… - … journal of cancer, 2020 - Wiley Online Library
Cervical cancer (CC) is the fourth most common cause of cancer death in women. The most
important risk factor for the development of CC is cervical infection with human papilloma …

Papillomavirus immune evasion strategies target the infected cell and the local immune system

C Zhou, ZK Tuong, IH Frazer - Frontiers in oncology, 2019 - frontiersin.org
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

TJ Kim, HT Jin, SY Hur, HG Yang, YB Seo… - Nature …, 2014 - nature.com
Here, we demonstrate that electroporation-enhanced immunization with a rationally
designed HPV DNA vaccine (GX-188E), preferentially targeting HPV antigens to dendritic …

Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity

CM Hebner, LA Laimins - Reviews in medical virology, 2006 - Wiley Online Library
Human papillomaviruses (HPVs) are small double‐stranded DNA viruses that infect the
cutaneous and mucosal epithelium. Infection by specific HPV types has been linked to the …

PIK3CA as an oncogene in cervical cancer

YY Ma, SJ Wei, YC Lin, JC Lung, TC Chang… - Oncogene, 2000 - nature.com
Amplification of chromosome arm 3q is the most consistent aberration in cervical cancer,
and is implicated in the progression of dysplastic uterine cervical cells into invasive cancer …

Clinician's guide to human papillomavirus immunology: knowns and unknowns

MH Einstein, JT Schiller, RP Viscidi… - The Lancet infectious …, 2009 - thelancet.com
Oncogenic human papillomavirus (HPV) is a common genital infection that has the potential
to develop into cervical cancer in some women. This Review summarises current knowledge …

Cell-mediated immune response to human papillomavirus infection

M Scott, M Nakagawa, AB Moscicki - Clinical Diagnostic …, 2001 - Am Soc Microbiol
Acquisition of human papillomavirus (HPV) results in an infection of variable duration which
may or may not be associated with clinically apparent lesions. Lesions caused by skintropic …

Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6

A de Jong, MIE van Poelgeest, JM van der Hulst… - Cancer research, 2004 - AACR
Cervical cancer is the possible outcome of genital infection with high-risk human
papillomavirus (HPV) and is preceded by a phase of persistent HPV infection during which …

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

S Daayana, E Elkord, U Winters, M Pawlita… - British journal of …, 2010 - nature.com
Background: Vulval intraepithelial neoplasia (VIN) is a premalignant condition, which is
frequently associated with type HPV16 infection, and multifocal disease has high rates of …

Chapter 4: Genital tract infections, cervical inflammation, and antioxidant nutrients—assessing their roles as human papillomavirus cofactors

PE Castle, AR Giuliano - Jnci Monographs, 2003 - academic.oup.com
Cervical infections by approximately 15 human papillomavirus (HPV) types are the
necessary cause of cervical cancer and its immediate precursor lesions. However …