The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

The role of the ZEB1–neuroinflammation axis in CNS disorders

E Poonaki, UD Kahlert, SG Meuth, A Gorji - Journal of Neuroinflammation, 2022 - Springer
Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–
mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of …

[HTML][HTML] Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia

A Almotiri, H Alzahrani… - The Journal of …, 2021 - Am Soc Clin Investig
JCI - Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid
leukemia Go to JCI Insight About Editors Consulting Editors For authors Publication ethics …

Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

D Liang, AL Elwell, N Aygün, O Krupa, JM Wolter… - Nature …, 2021 - nature.com
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements
active during cortical neurogenesis. However, it remains poorly understood as to how these …

Synthetic epigenetic reprogramming of mesenchymal to epithelial states using the CRISPR/dCas9 platform in triple negative breast cancer

C Waryah, J Cursons, M Foroutan, C Pflueger… - Advanced …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a reversible transcriptional program invoked by
cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of …

Post-translational modification of ZEB family members in cancer progression

MK Park, H Lee, CH Lee - International Journal of Molecular Sciences, 2022 - mdpi.com
Post-translational modification (PTM), the essential regulatory mechanisms of proteins, play
essential roles in physiological and pathological processes. In addition, PTM functions in …

[HTML][HTML] Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis

J Wang, S Xie, N Li, T Zhang, W Yao, H Zhao, W Pang… - Bioactive Materials, 2022 - Elsevier
Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in
response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be …

Zika virus neuropathogenesis: The different brain cells, host factors and mechanisms involved

TV Komarasamy, NAA Adnan, W James… - Frontiers in …, 2022 - frontiersin.org
Zika virus (ZIKV), despite being discovered six decades earlier, became a major health
concern only after an epidemic in French Polynesia and an increase in the number of …

ZEB1: New advances in fibrosis and cancer

L Cheng, MY Zhou, YJ Gu, L Chen, Y Wang - Molecular and Cellular …, 2021 - Springer
Zinc finger E-box binding homeobox 1 (ZEB1) is an important transcription factor in epithelial
mesenchymal transition (EMT) which participates in the numerous life processes, such as …

The transrepression and transactivation roles of CtBPs in the pathogenesis of different diseases

Z Chen - Journal of Molecular Medicine, 2021 - Springer
Gene transcription is strictly controlled by transcriptional complexes, which are assemblies
of transcription factors, transcriptional regulators, and co-regulators. Mammalian genomes …