Cheminformatics in natural product‐based drug discovery

Y Chen, J Kirchmair - Molecular Informatics, 2020 - Wiley Online Library
This review seeks to provide a timely survey of the scope and limitations of cheminformatics
methods in natural product‐based drug discovery. Following an overview of data resources …

[HTML][HTML] Potential natural products against respiratory viruses: a perspective to develop anti-COVID-19 medicines

M Omrani, M Keshavarz, S Nejad Ebrahimi… - Frontiers in …, 2021 - frontiersin.org
The emergence of viral pneumonia caused by a novel coronavirus (CoV), known as the
2019 novel coronavirus (2019-nCoV), resulted in a contagious acute respiratory infectious …

Identification of bioactive compounds from Glycyrrhiza glabra as possible inhibitor of SARS-CoV-2 spike glycoprotein and non-structural protein-15: a …

SK Sinha, SK Prasad, MA Islam, SS Gurav… - Journal of …, 2021 - Taylor & Francis
At present, the world is facing a pandemic named as COVID-19, caused by SARS-CoV-2.
Traditional Chinese medicine has recommended the use of liquorice (Glycyrrhiza species) …

Development of anti‐influenza agents from natural products

ZJ Zhang, SL Morris‐Natschke… - Medicinal research …, 2020 - Wiley Online Library
The influenza pandemic continues to threaten public health due to its high morbidity and
mortality rates, despite some successes in antiviral research. Natural drugs are important …

Influenza neuraminidase: a druggable target for natural products

U Grienke, M Schmidtke, S von Grafenstein… - Natural product …, 2012 - pubs.rsc.org
Covering: 2000 to 2011 The imminent threat of influenza pandemics and repeatedly
reported emergence of new drug-resistant influenza virus strains demonstrate the urgent …

[HTML][HTML] Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition

CJ Vavricka, Q Li, Y Wu, J Qi, M Wang, Y Liu… - PLoS …, 2011 - journals.plos.org
The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA)
inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant …

Identification of natural products inhibiting SARS-CoV-2 by targeting viral proteases: a combined in silico and in vitro approach

A Wasilewicz, B Kirchweger, D Bojkova… - Journal of Natural …, 2023 - ACS Publications
In this study, an integrated in silico–in vitro approach was employed to discover natural
products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, ie, main …

[HTML][HTML] Discovery of oseltamivir-based novel PROTACs as degraders targeting neuraminidase to combat H1N1 influenza virus

Z Xu, X Liu, X Ma, W Zou, Q Chen, F Chen, X Deng… - Cell insight, 2022 - Elsevier
Annual and sporadic influenza outbreaks pose a great threat to human health and the
economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen …

Potential anti-influenza effective plants used in Turkish folk medicine: A review

SA Sargin - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Due to the outbreaks such as SARS, bird flu and swine flu,
which we frequently encounter in our century, we need fast solutions with no side effects …

[HTML][HTML] New small-molecule drug design strategies for fighting resistant influenza A

Z Shen, K Lou, W Wang - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Influenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main
treatment strategies–vaccination and small molecule anti-influenza drugs are currently …