Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis

GK Reynolds, M Maclean, ERS Cliff, BW Teh… - Blood …, 2024 - ashpublications.org
Bispecific antibodies (BsAbs) have demonstrated efficacy in newly diagnosed and
relapsed/refractory (R/R) lymphomas. BsAbs form immune synapses between effector cells …

IgG replacement in multiple myeloma

A Wonnaparhown, T Hilal, J Squire, C Freeman… - Blood cancer …, 2024 - nature.com
T cell engagers (TCE) such as chimeric antigen receptor (CAR) T cell therapy and bispecific
antibodies (BiAbs) for the treatment of multiple myeloma (MM) have significantly improved …

Incidence, timing, and management of infections in patients receiving teclistamab for the treatment of relapsed/refractory multiple myeloma in the MajesTEC‐1 study

AK Nooka, C Rodriguez, MV Mateos, S Manier… - Cancer, 2024 - Wiley Online Library
Background Patients with relapsed/refractory multiple myeloma are at increased risk of
infection. Infections during treatment with teclistamab, the first B‐cell maturation antigen …

Bispecific antibodies: Advancing precision oncology

M Herrera, G Pretelli, J Desai, E Garralda, LL Siu… - Trends in Cancer, 2024 - cell.com
Bispecific antibodies (bsAbs) are engineered molecules designed to target two different
epitopes or antigens. The mechanism of action is determined by the bsAb molecular targets …

Teclistamab in relapsed refractory multiple myeloma: multi-institutional real-world study

M Mohan, J Monge, N Shah, D Luan, M Forsberg… - Blood cancer …, 2024 - nature.com
The objective of our study was to report real-world data on the safety and efficacy of
standard-of-care teclistamab in patients with relapsed/refractory multiple myeloma (MM) …

Sustained remission following finite duration bispecific antibody therapy in patients with relapsed/refractory myeloma

R Chakraborty, H Cheruvalath, A Patwari… - Blood Cancer …, 2024 - nature.com
Bispecific antibodies [bsAb] targeting B-cell maturation antigen [BCMA] and G-protein-
coupled receptor class C group 5 member D [GPRC5D] have demonstrated deep and …

A safety review of recently approved and emerging drugs for patients with relapsed or refractory multiple myeloma

S Midha, MA Hartley-Brown, CC Mo… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Multiple new drugs have been approved over the past 5 years for the treatment
of relapsed/refractory multiple myeloma (RRMM), and these are being increasingly widely …

Management of toxicities associated with BCMA, GPRC5D, and FcRH5-targeting bispecific antibodies in multiple myeloma

D Pan, J Richter - Current Hematologic Malignancy Reports, 2024 - Springer
Abstract Purpose of Review The introduction of bispecific antibodies is one of the most
significant recent advances in the treatment of relapsed/refractory multiple myeloma. This …

Improving infection reporting in hematology treatment trials

BW Teh, GK Reynolds, M Mikulska, NJ Mueller… - Blood …, 2024 - ashpublications.org
The authors raised salient points about the importance of accounting for differences in the
duration of follow-up and drug exposure between trials to reduce variation in reporting and …

T-cell redirecting bispecific antibody treatment in multiple myeloma: current knowledge and future strategies for sustained T-cell engagement

MR Heerma van Voss, RJ Molenaar… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction T-cell redirecting bispecific antibodies (BsAbs), targeting B-cell maturation
antigen (BCMA) or G-protein–coupled receptor class C group 5 member D (GPRC5D), are …