As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

It is well established that mutations in the canonical WNT-signalling pathway play a major
role in various cancers. Critical to developing new therapeutic strategies is understanding …

In plant cells, translation occurs in three compartments: the cytosol, the plastids and the
mitochondria. While the structures of the (prokaryotic-type) ribosomes in plastids and …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

The existence of naturally occurring ribosome heterogeneity is now a well-acknowledged
phenomenon. However, whether this heterogeneity leads to functionally diverse 'specialized …

Ribosomal proteins (RPs) constitute the ribosome, thus participating in the protein
biosynthesis process. Emerging studies have suggested that many RPs exhibit different …

Although differential transcription drives the development of multicellular organisms, the
ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation …

The ability of ribosomes to translate mRNAs into proteins is the basis of all life. While
ribosomes are essential for cell viability, reduction in levels of ribosomes can affect cell fate …

In addition to their central functions in translation, ribosomes can adopt inactive structures
that are fully assembled yet devoid of mRNA. We describe how the abundance of idle …

Ribosomes were known to be multicomponent complexes as early as the 1960s.
Nonetheless, the prevailing view for decades considered active ribosomes to be a …