Background: The human heart requires a complex ensemble of specialized cell types to
perform its essential function. A greater knowledge of the intricate cellular milieu of the heart …

Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process
that culminates in the formation of a scar whose structural characteristics dictate propensity …

Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues.
Elasticity is required in the heart for properly pumping blood to the whole body …

Intervertebral disc degeneration (IDD), which is caused by multiple factors, affects the health
of individuals and contributes to low back pain. The pathology of IDD is complicated, and …

The clinical impact of rare loss-of-function variants has yet to be determined for most genes.
Integration of DNA sequencing data with electronic health records (EHRs) could enhance …

Rationale: Cilp1 (cartilage intermediate layer protein 1) is a secreted extracellular matrix
protein normally associated with bone and cartilage development. Its function and …

Aims Hypertension is a major risk factor for cardiovascular diseases. However, vascular
remodelling, a hallmark of hypertension, has not been systematically characterized yet. We …

Decellularized-organ-derived extracellular matrix (dECM) has been used for many years in
tissue engineering and regenerative medicine. The manufacturing of hydrogels from dECM …

Cardiac fibrosis is a pathological process associated with various forms of heart failure. This
study identified latent transforming growth factor-β binding protein 2, cartilage oligomeric …

Rheumatic joints have an altered cartilage turnover. Cartilage intermediate layer protein 1
(CILP-1) is secreted from articular chondrocytes and deposited into the cartilage …