Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

A Annamneedi, C Gora, A Dudas… - British journal of …, 2023 - Wiley Online Library
Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two
core symptoms: deficits in social interaction and communication, and stereotyped …

Zebrafish modeling of autism spectrum disorders, current status and future prospective

A Tayanloo-Beik, SK Hamidpour, M Abedi… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a complicated range of childhood
neurodevelopmental disorders which can occur via genetic or non-genetic factors. Clinically …

Biomarker exploration in human peripheral blood mononuclear cells for monitoring sulforaphane treatment responses in autism spectrum disorder

H Liu, AW Zimmerman, K Singh, SL Connors… - Scientific reports, 2020 - nature.com
Abstract Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental
disorders with no drugs treating the core symptoms and no validated biomarkers for clinical …

[HTML][HTML] Drug development for autism spectrum disorder (ASD): progress, challenges, and future directions

JT McCracken, E Anagnostou, C Arango… - European …, 2021 - Elsevier
In 2017, facing lack of progress and failures encountered in targeted drug development for
Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM …

Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model

A Reichova, Z Bacova, S Bukatova… - Molecular and Cellular …, 2020 - Elsevier
Oxytocin has been suggested as a potential therapeutic agent in autism and other
neuropsychiatric conditions. Although, the link between the deficit in “SH3 domain and …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models

S Pietropaolo, G Marsicano - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Recent years have seen an impressive amount of research devoted to understanding the
etiopathology of Autism Spectrum Disorder (ASD) and developing therapies for this …

A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder

SS Purushotham, NMN Reddy, MN D'Souza… - Experimental Brain …, 2022 - Springer
Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2 …

The effect of background strain on the behavioral phenotypes of the MDGA2+/− mouse model of autism spectrum disorder

E Fertan, AA Wong, MK Purdon… - Genes, Brain and …, 2021 - Wiley Online Library
The membrane‐associated mucin (MAM) domain containing glycosylphosphatidylinositol
anchor 2 protein single knock‐out mice (MDGA2+/−) are models of ASD. We examined the …

[HTML][HTML] Measuring the replicability of our own research

RE Brown - Journal of Neuroscience Methods, 2024 - Elsevier
In the study of transgenic mouse models of neurodevelopmental and neurodegenerative
disorders, we use batteries of tests to measure deficits in behaviour and from the results of …