Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Neurons require unique subcellular compartmentalization to function efficiently. Formed
from proteins and RNAs through liquid–liquid phase separation, membraneless organelles …

Traumatic brain injury (TBI) strongly correlates with neurodegenerative disease. However, it
remains unclear which neurodegenerative mechanisms are intrinsic to the brain and which …

Amyotrophic lateral sclerosis (ALS) and Frontotemporal Degeneration (FTD) are
neurodegenerative disorders, related by deterioration of motor and cognitive functions and …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized in its
typical presentation by a combination of lower and upper motor neuron symptoms, with a …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in a
gradual loss of motor neuron function. Although ophthalmic complaints are not presently …

Background Understanding the genetic modifiers of neurodegenerative diseases can
provide insight into the mechanisms underlying these disorders. Here, we examine the …

The development of high-throughput sequencing technologies and screening of big patient
cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification …

Background: Increasing evidence has highlighted retinal impairments in neurodegenerative
diseases. Dominant mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic …

The presence of microsatellite repeat expansions within genes is associated with> 30
neurological diseases. Of interest,(GGGGCC)> 30-repeats within C9orf72 are associated …