The Mitsunobu reaction is widely regarded as the pre-eminent method for performing
nucleophilic substitutions of alcohols with inversion of configuration. However, its …

We present a new, unified approach for the transformation of benzylic and allylic alcohols,
aldehydes, and ketones into boronic esters under electroreductive conditions. Key to our …

Nucleophilic substitutions (SN) account for the most essential and frequently applied
chemical transformations. SN‐reactions allow forging C–C, C–O, C–N and C–Cl bonds, for …

The ability to efficiently synthesize desired compounds can be a limiting factor for chemical
space exploration in drug discovery. This ability is conditioned not only by the existence of …

Aminophosphines derived from N, N′-disubstituted ethylenediamines (R–N (H) CH2CH2N
(H)–R; R= ortho-tolyl, phenyl, benzyl, iso-propyl, and n-octyl) were used to adjust the kinetics …

A highly sustainable catalytic protocol for the coupling of alcohols and amines for selective
monoalkylated amines using Ni (II)–NΛNΛO pincer type complexes through the borrowing …

We developed a Ru/hemilabile-ligand-catalyzed nucleophilic aromatic substitution (SNAr) of
aryl fluorides as the limiting reagents. Significant ligand enhancement was demonstrated by …

Herein, we report a highly effective homogeneous methodology for the N-alkylation of
amines with primary and secondary alcohols using a Co (II)-complex of an inverse triazolyl …

A highly sustainable, bench-stable, N-heterocyclic carbene based organocatalyst has been
demonstrated to impersonate the role of a transition-metal catalyst which had already been …

By using cheap and innocuous reagents, such as NaClO2, NaOCl, and catalytic amounts of
TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C …