Malaria genomics, vaccine development, and microbiome

X Su, RV Stadler, F Xu, J Wu - Pathogens, 2023 - mdpi.com
Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …

Suppression of drug resistance reveals a genetic mechanism of metabolic plasticity in malaria parasites

AM Guggisberg, PM Frasse, AJ Jezewski, NM Kafai… - MBio, 2018 - Am Soc Microbiol
In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic
intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits …

Anti-malarial activity of new N-acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLN) derivatives against Plasmodium falciparum

HJ Choi, M Cui, DY Li, HO Song, HS Kim… - Bioorganic & medicinal …, 2013 - Elsevier
Malaria is the most common of the parasitic diseases in tropical and subtropical regions.
Adverse side effects of anti-malarial drugs have precluded them as a potential clinical drug …

Localization of the putative recombinase Pf-int to the apicoplast of Plasmodium falciparum

AV Berglar, SS Vembar, DN Gopaul - bioRxiv, 2021 - biorxiv.org
Diseases caused by apicomplexan parasites, such as malaria and toxoplasmosis cause∼
200 million (worldwide) and 1 million (Europe) infections, respectively, every year …