Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Integrin-mediated adhesion is regulated by multiple features of the adhesive surface,
including its chemical composition, topography, and physical properties. In this study we …

Lamellipodia, filopodia and membrane ruffles are essential for cell motility, the organization
of membrane domains, phagocytosis and the development of substrate adhesions. Their …

▪ Abstract The conversion of physical signals, such as contractile forces or external
mechanical perturbations, into chemical signaling events is a fundamental cellular process …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the
mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged …

Cell migration is an integrated process that requires the continuous, coordinated formation
and disassembly of adhesions. These processes are complex and require a regulated …

Cellular locomotion is driven by repeated cycles of protrusion of the leading edge, formation
of new matrix adhesions and retraction of the trailing edge. In this study we addressed the …

Cell motility requires lamellipodial protrusion, a process driven by actin polymerization.
Ena/VASP proteins accumulate in protruding lamellipodia and promote the rapid actin …