Methotrexate safety and efficacy in combination therapies in patients with early rheumatoid arthritis: A Post Hoc Analysis of a Randomized Controlled Trial

K Lend, FA Koopman, J Lampa, G Jansen… - Arthritis & …, 2024 - Wiley Online Library
Objective We investigated methotrexate safety and the influence of dose on efficacy
outcomes in combination with three different biologic treatments and with active …

MTHFR and MTRR Genetic Polymorphism of Methotrexate Therapy Outcomes in Early Rheumatoid Arthritis

Q Zhang, P Fu, Z Cao, H Huang, Q Wen… - Pharmacogenomics …, 2023 - Taylor & Francis
Purpose Methotrexate (MTX) is used as an anchor drug for the treatment of rheumatoid
arthritis (RA) and there may be differences in drug action between genotypes. The purpose …

Variations in Genetic Factors Impacting the Effectiveness and Side Effects of Methotrexate with Rheumatoid Arthritis

A Alharthi, R Magadmi, M Hassan… - International Journal of …, 2024 - ijpras.com
This review provides a comprehensive overview of genetic variations influencing the efficacy
and side effects of methotrexate (MTX) treatment in rheumatoid arthritis (RA) patients. It …